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Research programs Research
Interests Techniques Representative Projects FAQ
Research programs
Small Organic Molecules (SOM) can have a variety of biological functions such as
cell signaling molecules, tools in molecular biology, drugs in medicine, or
pesticides in farming. SOM can be natural or synthetic; they may have a
beneficial effect against a disease (such as drugs) or may be detrimental
(such as carcinogens). SOM are valuable for treating diseases and
constitute most medicines marketed today. SOM are suitable tools for
understanding the living systems and thus can provide a smoother transition
from chemistry to biology to medicine.
Our research programs
aim at the development of biologically interesting small organic molecules
that may lead to clinically applicable applicable
pharmaceutical drugs.
Based on our broad
research experience, we design and perform the chemical syntheses of the
new target compounds; compound libraries can be synthesized on automated
simultaneous multiple chemical synthesizers. Following their purification
(HPLC) and characterization (NMR, MS), the compounds will undergo in vitro
and in vivo studies.
Research Interests
· Cancer
chemotherapy · Drug
targeting
· Drug
delivery systems in oncology ·
Bioconjugate chemistry
·
Macromolecular prodrugs · Prodrugs in oncology
· Circumventing
multidrug resistance · Receptor
and antigen targeting
·
Multifunctional-acting prodrugs · Tumor-associated protease
Techniques
· Drug Synthesis
- Synthesis of multicyclic ring systems
- Multicomponent reactions in drug synthesis
- Solid-phase
peptide-synthesis
- Automated
solid-phase peptide-synthesis
- Microwave-assisted
synthesis
- Synthesis of substance libraries
- SPOT-synthesis of
compound libraries
· HPLC and LC-MS Drug analyses:
- Reaction monitoring
- Determination of purity
profile
- Determination of
stability profile of a drug candidate during its production
- Determination of
stability profile of a drug candidate during the lyophilization process
- Determination of
stability profile of a drug candidate during the reconstitution process
- Determination of
stability profile of a drug candidate in an injection buffer for biological
studies
- Determination of
stability profile of a drug candidate in human plasma and mouse plasma
- Drug release
studies
 
Representative
example for HPLC drug release study of the albumin conjugates
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